Name of Subject  : BIO-INFORMATICS (7 IT 6.3)

Unit

Contents

INTRODUCTION:

Bioinformatics objectives and overviews, Interdisciplinary nature of Bioinformatics, Data

integration, Data analysis, Major Bioinformatics databases and tools. Metadata: Summary & reference systems,

finding new type of data online.

I

MOLECULAR BIOLOGY AND BIOINFORMATICS:

Systems approach in biology, Central dogma of molecular

biology, problems in molecular approach and the bioinformatics approach, Overview of the bioinformatics

applications.

THE INFORMATION MOLECULES AND INFORMATION FLOW: Basic chemistry of nucleic acids, Structure of

DNA, Structure of RNA, DNA Replication, -Transcription, -Translation, Genes- the functional elements in DNA,

II

Analyzing DNA,DNA sequencing. Proteins: Amino acids, Protein structure, Secondary, Tertiary and Quaternary

structure, Protein folding and function, Nucleic acid-Protein interaction.

PERL: Perl Basics, Perl applications for bioinformatics- Bioperl, Linux Operating System, Understanding and Using

III

Biological Databases, Java clients, CORBA, Introduction to biostatics.

NUCLEOTIDE SEQUENCE DATA: Genome, Genomic sequencing, expressed sequence tags, gene expression,

transcription factor binding sites and single nucleotide polymorphism. Computational representations of molecular

IV

biological data storage techniques: databases (flat, relational and object oriented), and controlled vocabularies,

general data retrieval techniques: indices, Boolean search, fuzzy search and neighboring, application to biological

data warehouses.

BIOLOGICAL DATA TYPES AND THEIR SPECIAL REQUIREMENTS: sequences, macromolecular structures,

V

chemical compounds, generic variability and its connection to clinical data. Representation of patterns and